How size difference between De La Hoya and Pacquiao affects fight

De La Hoya vs. Pacquiao has been billed as a David vs. Goliath battle, with Manny Pacquiao having just moved up to lightweight (135 lbs) in June to fight David Diaz, while Oscar De La Hoya has fought as high as middleweight (160 lbs). How would this significant size difference play in determining the outcome of the fight?

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