SPRINGFIELD, Mo. (AP) -- Gregory Echenique scored 16 points, and Doug McDermott added 15 to help No. 19 Creighton beat Missouri State 66-65 on Wednesday night.
Echenique was 5 of 6 from the field, made all six of his free throws and added seven rebounds for the Bluejays (17-2, 7-1 Missouri Valley Conference).
Anthony Downing had 14 points for Missouri State (11-9, 4-4), which beat Creighton in Omaha on Dec. 28. Kyle Weems added 13 points for the Bears, 11 in the second half.
Missouri State had two late chances, but missed both shots en route to its third straight loss.
Weems missed a jumper from the baseline, and McDermott was fouled on the rebound with 6.4 second left.
McDermott then missed a free throw, giving the Bears another chance.
Missouri State's Caleb Paterson grabbed the rebound and passed to Downing, who drove the length of the court and missed a jumper from near the free-throw line as time expired.
Creighton, which trailed 56-53 with 7:37 left, took the lead at 61-58 on Josh Jones' 3-pointer with 4:46 left. The Bears rallied to tie it at 63 with 2:50 to play on Weems' jumper and Downing's two free throws.
Grant Gibbs scored with 1:06 left to give Creighton a 66-63 lead, and Jarmar Gulley completed the scoring with 55.1 seconds left.
There were 16 ties and 10 lead changes. Creighton's biggest lead was four, and Missouri led by eight early in the second half.