Carlos Emory led five double-figures scorers with 16 points for Oregon in an 80-59 win against Arkansas-Pine Bluff on Saturday.
Arsalan Kazemi and Daymean Dotson scored 11 each for the Ducks (7-1), who are off to their best start since opening 8-1 in 2007, and Dominic Artis and E.J. Singler had 10 points each.
Kazemi also had a game-high 13 rebounds and five steals.
Mitchell Anderson scored 16 to lead the Golden Lions (1-6), who lost to a team from the Pac-12 Conference for the third time this season after earlier defeats to Arizona State and Washington State.
Oregon led 37-30 at halftime and put the game away with a 20-2 run early in the second half.
Artis had six points during that stretch, and Emory and Singler had five points each as Oregon went up 57-34 with 13:52 to play.