Travis Buck drove in two runs, Justin Maxwell homered in his Houston debut and the Astros rebounded from an early deficit thanks to sloppy defensive play by the Atlanta Braves in an 8-3 win on Monday night.
The loss drops Atlanta to 0-4 for the first time since losing 10 straight to open the 1988 season. The Astros are 3-1 after finishing last season with baseball's worst record.
Houston trailed 3-0 in the third before a trio of errors by the Braves, with two from third baseman Juan Francisco, led to three unearned runs and tied the game.
Astros starter J.A. Happ drove in the go-ahead run with an RBI single in the fourth inning that made it 4-3. Pinch-hitter J.D. Martinez and Jose Altuve drove in a run each in the sixth to stretch the lead to 6-3.
Happ (1-0) allowed six hits and three runs with five strikeouts in six innings for the win.
Braves starter Brandon Beachy (0-1) allowed four hits and four runs - one earned - in five innings.
Maxwell, acquired from the Yankees on...