Bryan LaHair homered and hit a game-winning single in the ninth inning, and the Chicago Cubs beat Houston 5-4 Wednesday in the Astros' National League finale.
In the first series between 100-game losers in the major leagues since 1962, LaHair homered in the second and broke a 4-all tie in the ninth against Hector Ambriz (1-0).
Houston went 55-107 and set a club record for losses with one more than last year. The Astros became the first team with 106 or more losses in consecutive seasons since the 1964-65 New York Mets.
Houston finished its NL tenure with 3,999 regular-season wins and 4,134 losses with five ties. The Astros are moving to the AL West next season, creating three divisions of five teams in each league.
The Astros was 16-25 under interim manager Tony DeFrancesco, who took over after Brad Mills was fired on Aug. 18. Washington third base coach Bo Porter already has been hired as Houston's manager for next season.
The Cubs, who haven't won the World Series since 1908,...