Originally posted on Pro Sports Daily  |  Last updated 7/25/12

SAN FRANCISCO -- Jesus Guzman hit a pair of home runs and had three RBIs and Chase Headley also homered, lifting the the San Diego Padres to a 6-3 win over the San Francisco Giants on Wednesday afternoon.

Jason Marquis (6-9) pitched 7 1/3 innings gave up three hits, one earned run, walked one, and struck out eight for his third consecutive victory, which avoided avoided a sweep in the three-game series.

In 10 starts for the Padres since he cleared release waivers, Marquis is 4-5 with a 3.48 ERA. He was 2-4 with an 8.47 ERA in seven starts with the Minnesota Twins.

Huston Street pitched the final four outs for his 17th save.

Tim Lincecum's nightmare season continued. The two-time Cy Young winner (4-11) lasted 4 2/3 innings, gave up seven hits, five earned runs, walked three, struck out eight, issued two wild pitches and hit a batter.

After Lincecum recorded two strikeouts in the top of the first, Headley got the Padres on the board with a home run to deep left-center.

In the fourth inning, Lincecum gave up singles to Guzman and John Baker. With two outs, Max Venable hit a low liner to left-center just out of reach of Giants center fielder Angel Pagan, allowing two runs to score.

Guzman hit the decisive blow in the fifth inning, crushing an 89 mph Lincecum fastball to the bleachers in left.

Without Buster Posey or Pablo Sandoval in the starting lineup, the Giants had difficulty generating any offense.

In the first, Gregor Blanco singled to right-center. He stole second base, advanced to third on a sacrifice bunt. Blanco scored on a sacrifice fly to left field by Melky Cabera.

The Giants would not get another hit until Angel Pagan's double with two outs in the seventh inning.

The Giants got a break in the eighth, scoring two runs. Brandon Belt grounded to short but Everth Cabrera threw the ball in the dirt and it bounced into the dugout allowing Belt to reach second on the two-base throwing error. Joaquin Arias singled to short moving Belt to third base. Marquis uncorked a wild pitch that scored Belt and Arias went to second.

Arias made a mental mistake, trying to advance on a ground ball hit deep in the hole at short By Eli Whiteside. Cabrera had no play to get Whiteside but threw out Arias at third base for the first out of the inning. Nate Schierholtz blooped a single to left, off reliever Joe Thatcher. Blanco grounded to third and Schierholtz was erased at second on the force out. With runners at first and third against Luke Gregorson, Ryan Theriot singled to right-center bringing in the third run of the inning.

With runners at the corners, Padres closer Huston Street was summoned from the bullpen and struck out Melky Cabrera to end the threat.

NOTES: The Giants are 6-15 in Lincecum's 21 starts. Lincecum has a 5.88 ERA, highest among National League qualifying pitchers. ... An MRI confirmed that Sandoval has a left hamstring strain. With an off-day Thursday, Giants manager Bruce Bochy said the team will wait until Friday to decide whether Sandoval needs to be put on the disabled list. ... Brandon Belt was 0-for-16 prior to his double in the ninth inning. ... San Diego scored five of its runs with two outs. ... Guzman is a former Giant and played in 12 games for San Francisco in 2009.

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