Derrick Williams had 21 points to help the Minnesota Timberwolves beat the Spurs 108-95 Wednesday night, ending a 16-game losing streak at San Antonio.
Chase Budinger added 15 points and Greg Stiemsma and Ricky Rubio had 12 points apiece for Minnesota, won on the Spurs' home court for the first time since Jan. 14, 2004.
Gary Neal had 17 points, Tim Duncan had 17 points and 14 rebounds, Tony Parker had 15 points and eight assists for the Spurs, who had previously clinched the Western Conference's second seed.
Duncan, Parker and Manu Ginobili did not play in the final quarter of the regular season finale.
San Antonio opens the playoffs by hosting either the Houston Rockets or the Los Angeles Lakers, who were playing later Wednesday night with the seventh seed at stake.
The Timberwolves outscored the Spurs 52-34 in the second half as Minnesota was 12 for 29 on 3s.
The Timberwolves opened the second half on a 9-2 run to take a 65-63 lead en route to the victory.