Originally written on NFL Injury Report  |  Last updated 11/18/14

MINNEAPOLIS - SEPTEMBER 27: Joe Staley #74 of the San Francisco 49ers reacts to a play while sitting on the bench during a game against the Minnesota Vikings at the Hubert H. Humphrey Metrodome on September 27, 2009 in Minneapolis, Minnesota. The Vikings defeated the 49ers 27-24. (Photo by Jonathan Daniel/Getty Images)
The San Francisco 49ers have three players that are listed as questionable as they head into tonight’s contest against the Seattle Seahawks, reports Brian McIntyre of Yahoo! Sports; offensive lineman Joe Staley (concussion), wide receiver Mario Manningham (shoulder) and running back Brandon Jacobs (knee). The 49ers could be without left tackle Joe Staley, who has to pass the league's concussion protocol before being cleared to play. Staley is officially listed as "questionable", as are wide receiver Mario Manningham (shoulder) and running back Brandon Jacobs (knee). Staley will have to pass the league’s concussion tests after sustaining a head injury Sunday during the team’s loss to the New York Giants. Manningham, who’s hampered by a shoulder injury, has caught 24 passes for 258 yards and one touchdown over his first six games of the season. Follow @TheNFLInjuryRpt
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