The NFL regular season finally kicks off this week, but there are already plenty of injury concerns. Some will keep players out to begin the season, while others could hamper players' performances.
So which injuries could have the biggest impacts in Week 1? Here are some of the biggest health concerns as the NFL season kicks off.
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Nursing an ankle injury that he suffered in the preseason, Beckham is questionable in a Week 1 matchup against Dallas. The Giants will rely on newcomer Brandon Marshall more if Beckham is unable to go.
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Bucannon had offseason ankle surgery and aggravated his injury two weeks ago. He will miss Arizona's Week 1 matchup against Detroit, which could be problematic against Matthew Stafford.
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The first overall pick in the 2017 draft, Garrett's regular-season debut will be delayed due to a high ankle sprain. He suffered the injury in Wednesday's practice.
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An important part of Chicago's defensive line, Goldman is week-to-week due to a concussion suffered in the preseason. At best, he seems questionable for Week 1.
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Detroit's third-round pick gained plenty of fans on the Lions coaching staff this summer. He's been nursing a minor ankle injury but should be able to play this week.
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A fifth-round pick, Kittle has emerged atop the 49ers' depth chart at tight end. He aggravated his hamstring during Wednesday's practice, which clouds his status for Week 1.
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Kupp was taken in the third round of the draft and is slated to get plenty of snaps for the Rams. However, his status for Week 1 is up in the air due to an ankle injury.
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Chicago's key offensive lineman missed significant time in 2016 with a fractured ankle, and he's very questionable for Week 1. Regular center Cody Whitehair has been taking snaps at guard in Long's absence.
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Luck will miss Indy's Week 1 matchup against the Rams as he continues to recover from offseason shoulder surgery. The Colts will roll with Scott Tolzien at quarterback for at least one game and possibly more, though the newly acquired Jacoby Brissett could see time too.
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Mack sat out practice on Wednesday due to a knee injury. There's no word on the severity, but he hadn't missed time previously.
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Matthews missed time in the preseason since being traded to Buffalo with a chest injury, but he's been practicing this week. The Bills expect him to be their No. 1 wide receiver vs. the Jets.
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Miller has been out for much of the preseason due to an ankle injury, but the Texans expect him to play this week. His presence will be key with Will Fuller injured and Jaelen Strong missing Week 1 due to a suspension.
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The Patriots lost Julian Edelman for the year during the preseason, and Mitchell is a game-time decision for Thursday's game due to a knee injury. If he's unable to play, former Colt Phillip Dorsett will likely get more snaps.
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The Chiefs will be without Nelson, their No. 2 cornerback, for the first eight weeks of the season due to a core muscle injury. It's a tough injury as the Chiefs visit the high-powered Patriots for their season opener.
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The oft-injured Rawls is expected to share playing time with Eddie Lacy this season, but his status is uncertain in Week 1 due to an ankle injury. Lacy will get more snaps, along with C.J. Prosise and Chris Carson, if Rawls can't go.
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The record holder in the 40 at the NFL Combine, Ross will miss at least two weeks due to a knee injury. He had a history of knee problems in college at Washington.
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Thomas was held out of practice early this week with a groin injury, but he returned on Wednesday. He's likely to play in the season opener against the Chargers.
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Yeldon has been out for nearly three weeks after suffering a hamstring injury during the preseason. Now the backup to rookie Leonard Fournette, Yeldon looks unlikely for Week 1.