NFL Week Three Spreads and Picks: Vikings-49ers, Lions-Redskins, Bears-Seahawks

NFL Betting—Week Three Picks NFL Week Three matchups are here already. Hard to believe how quickly the season is going. We’ve already seen a massive upset happen—how about those Bengals over the Packers?—and there could be an even bigger one on the horizon this weekend. Let’s make a few NFL picks. San Francisco 49ers at Minnesota Vikings Sunday, Sept. 27, 1 p.m. ET NFL betting favorite: Vikings -6.5 Here’s our chance to find out if San Francisco is truly for real. Frank Gore destroyed Seattle’s defense last week, racking up 207 rushing yards, but he faces the formidable Minnesota run defense led by Pat and Kevin Williams this week. If (when?) the Vikes stack the box and bottle up Gore, Shaun Hill will have to do more than caretake from the quarterback position. I’m not so sure he’s up to the task. San Fran’s “D” looks excellent under Mike Singletary but hasn’t faced a tailback anywhere close to Adrian Pete...