Baltimore Ravens star running back Ray Rice and Washington Redskins tight end Fred Davis were among players to be tagged Friday.
Atlanta Falcons cornerback Brent Grimes also received the franchise tag.
On Thursday, the Philadelphia Eagles wide receiver DeSean Jackson was hit with the franchise tag, which guarantees a player to be paid among the top five at his position or at a salary that is 120 percent higher than the previous season.
Rice is coming off a stellar season with the Ravens, rushing for a career-high 1,364 yards and 12 touchdowns in leading the team to the NFC North title.
Davis had 59 receptions for 796 yards and three touchdowns in 12 games before his season was cut short by a four-game suspension for violating the league's policy on banned substances.