Defending champion Andy Murray could face top-seeded Novak Djokovic only in the U.S. Open semifinals, while Rafael Nadal and Roger Federer -- who have never played each other at Flushing Meadows -- might meet in the quarterfinals.
Murray earned his first Grand Slam championship by beating Djokovic in the 2012 U.S. Open final, then added a second by beating the No. 1-ranked Serb in the Wimbledon title match last month. But there can't be a rematch in New York in the final, thanks to Thursday's draw.
Play at the year's last Grand Slam tournament begins Monday.
In addition to No. 2 Nadal against No. 7 Federer, a 17-time major champion who has his lowest seeding at the U.S. Open since he was 13th in 2002, the other possible men's quarterfinals are 2011 champion Djokovic vs. 2009 champion Juan Martin del Potro, No. 3 Murray vs. No. 5 Tomas Berdych, and No. 4 David Ferrer vs. No. 8 Richard Gasquet.
Federer, who owns five U.S. Open titles, and Nadal also were set up for a possible quar...