Dillon Gabriel threw for 400 yards and three touchdowns to lift No. 13 Oklahoma to a 69-45 win over TCU on Friday in Norman, Okla.
Gabriel moved into seventh place in NCAA career passing yards in the win, passing three players including former Sooners' quarterback Baker Mayfield on the list.
Gabriel now has 14,865 career passing yards.
The Sooners' 69 points were their most in a conference game since beating Texas A&M 77-0 in 2003.
Oklahoma (10-2, 7-2 Big 12) kept its hopes alive to make the Big 12 Championship Game by recording its third straight win.
Friday's game was the Sooners' final Big 12 regular-season game. They'll move to the Southeastern Conference next season.
The loss leaves the Horned Frogs short of a bowl berth just one season after making the College Football Playoff title game.
TCU (5-7, 3-6) lost four of its last five games.
After being injured a week ago in a win at BYU, Gabriel's status was up in the air in a short week.
But Gabriel showed little effects of the injury from the start.
He completed a 50-yard pass on the first drive to set up his own 8-yard touchdown run, then later in the first connected with Jayden Gibson for a 59-yard score.
His 53-yard touchdown to Brenen Thompson started a second-quarter onslaught for the Sooners, who scored 28 points in the quarter and shut down the Horned Frogs' offense to take a 42-16 lead into the break.
But TCU didn't go away, pulling within 14 in the third quarter.
Oklahoma finally put the game away in the fourth quarter, going up 62-38 on Gavin Sawchuk's 9-yard touchdown run.
Sawchuk, who finished with 22 carries for 130 yards, scored three touchdowns for his first career multi-touchdown game.
Drake Stoops had 12 catches for 125 yards and a touchdown.
Emani Bailey rushed for 150 yards and a touchdown for TCU while Josh Hoover threw for 344 yards and four touchdowns.
Oklahoma's Billy Bowman returned an interception for a score for the second consecutive game, bringing back his pick of Hoover 45 yards for a score in the fourth quarter.
Bowman leads the Big 12 with six interceptions, returning three for touchdowns.
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