Dillon Gabriel threw for 366 yards and three touchdowns and ran for two more as No. 14 Oklahoma beat visiting Iowa State 50-20 on Saturday in Norman, Okla.
The Sooners (5-0, 2-0 Big 12) scored the last 29 points of the game after Iowa State cut it to a one-point game early in the second quarter.
It was the most passing yards given up by the Cyclones (2-3, 1-1) in nearly two years.
Jalil Farooq led the Sooners with five catches for 81 yards.
The Sooners led 21-10 after the first quarter thanks to a 44-yard interception return for a touchdown by Billy Bowman, Gabriel's first rushing touchdown, and a 39-yard touchdown pass from Gabriel to Nic Anderson.
But the Cyclones came back over the next six minutes, pulling to within one on Chase Contreraz's 48-yard field goal at 9:06 before halftime.
From there, though, the Sooners took control.
Gabriel hit Farooq for a 49-yard gain to set up his own 6-yard touchdown run, then Peyton Bowen's blocked punt resulted in a safety to stretch the lead.
Oklahoma followed that up with a field goal and then Gabriel hit Drake Stoops for a touchdown in the final seconds of the second quarter to send the Sooners into halftime up 40-20.
Stoops' touchdown was set up by Gentry Williams' interception -- Oklahoma's 10th of the season.
Then Oklahoma kept it going coming out of halftime, as Gabriel hit Jayden Gibson for a 41-yard touchdown to stretch the lead to 47-20 and make Gabriel the first 300-yard passer against Iowa State since late in the 2021 season.
Rocco Becht finished 15 of 33 for 188 yards and two touchdowns -- with two interceptions -- for the Cyclones. More than half of those yards -- 118 -- came on his two touchdown passes.
After posting 270 yards in the first half, Iowa State managed just 82 yards of offense in the second half -- only 29 on the ground.
Oklahoma outgained the Cyclones 523-352 overall.
Jayden Higgins, who scored on a 67-yard reception, led Iowa State with three catches for 91 yards.
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