Michael McLoone-USA TODAY Sports

William Contreras and Carlos Santana hit back-to-back home runs in the fifth as the host Milwaukee Brewers rallied for a 5-3 victory over the Washington Nationals on Friday night in the opener of a three-game series.

Contreras hit a three-run homer and Santana followed with a solo shot to allow Milwaukee (83-64) to erase a three-run deficit. The Brewers had mustered just one hit -- Brice Turang's leadoff single in the third -- prior to the decisive fifth.

Santana went deep again in the eighth to provide Milwaukee with an insurance run. It was his 21st homer of the season.

One day after four relievers combined to allow just one hit over four innings in a win over the Miami Marlins, the Brewers' bullpen was strong once again. Trevor Megill tossed 1 1/3 scoreless innings and Abner Uribe worked a 1-2-3 eighth before Devin Williams struck out the side in the ninth.

Williams secured his 35th save of the season.

Milwaukee's fifth-inning outburst made a winner of left-hander Wade Miley (8-4), who settled down after a sloppy first inning.

After Lane Thomas hit a one-out solo shot in the opening frame, Joey Meneses doubled to right. One out later, Carter Kieboom and Ildemaro Vargas laced back-to-back RBI doubles to provide Washington (65-83) with a 3-0 lead.

But Miley then settled in, keeping the Nationals hitless over the final 4 2/3 innings of his outing. He ended up exiting after Kieboom singled in the sixth, having given up the three runs on five hits in 5 2/3 innings.

Nationals starter Jake Irvin (3-6) held the Brewers at bay in the early going before the hosts got to him in the fifth. Irvin lasted 4 2/3 innings, allowing four runs on three hits. He walked five and struck out six.

Milwaukee now holds a five-game lead over the Cubs in the National League Central. Chicago was set to play the Diamondbacks later Friday night.

More must-reads:

TODAY'S BEST
Rafael Nadal switches gears, gives major update on French Open status
Atlanta to be first race of NASCAR's In-Season Tournament
West Point alum made history in his MLB debut with Reds
Heat legend cautions Lakers against hiring JJ Redick
Welcome to the WNBA: Caitlin Clark sets infamous record in debut
Jalen Brunson leads Knicks to blowout win in Game 5 vs. Pacers
Nikola Jokic torches DPOY to lead Nuggets past Wolves in Game 5
Oilers use late heroics to tie Canucks at two games each
Watch: Astros pitcher ejected after foreign substance check
Kirk Cousins not angry with Falcons because winning is 'hard enough'
Bronny James has surprising comments on potentially teaming up with LeBron
Bills add two-time Super Bowl champ to new-look WR room
Brewers lose team-leading home run hitter to injured list
Sandy Alderson denies involvement in Mets, Billy Eppler IL controversy
Twins reliever shut down for six weeks with patellar tendon tear
Chris Finch throws shade at Nuggets star over Rudy Gobert’s fine
Cardinals head coach warns not to bet against Kyler Murray
Details emerge on Jason Kelce’s role at ESPN
Rangers defenseman wins Mark Messier Leadership Award
Ex-NFL head coach takes over as Arena Football League commish

Want more Brewers news?

Join the hundreds of thousands of fans who start their day with Yardbarker's Morning Bark, the best newsletter in sports.