Orlando Ramirez-USA TODAY Sports

Right-hander Chris Flexen shut out San Diego on four hits over 6 2/3 innings, Cal Raleigh drove in four runs and rookie Julio Rodriguez hit a tape-measure, two-run homer Monday afternoon as the visiting Seattle Mariners defeated the Padres 8-2.

The win in the opener of a two-game interleague series was the Mariners' sixth in the past seven games. Seattle is 11-3 over their past 14 games. The Padres are 2-7 over their past nine games.

Flexen (5-8) retired the first 10 Padres he faced before issuing a walk to Manny Machado with one out in the fourth. Jake Cronenworth followed with the first of the Padres' hits off Flexen, who issued three walks and struck out eight.

Meanwhile, the Mariners were scoring four runs off Sean Manaea in 3 1/3 innings in the left-hander's shortest start of the season. Manaea (3-4) gave up eight hits and four walks with three strikeouts.

The Mariners scored twice in the first. One-out singles by J.P. Crawford and Eugenio Suarez were followed by a to Carlos Santana. Crawford scored on Raleigh's groundout, and Abraham Toro followed with an RBI double.

Rodriguez's homer onto the upper balcony of the Western Metal Supply Co. building in left came one out after Dylan Moore's inning-opening single in the fourth.

Raleigh hit a three-run double off reliever Taylor Scott in the sixth. Rodriguez reached on a throwing error by third baseman Machado to open the inning. Crawford followed with a single, and Santana drew a one-out walk to load the bases for the catcher.

Seattle added an unearned run on a throwing error by Padres relief pitcher Tim Hill in the eighth.

Santana reached base in all five plate appearances with two hits and three walks, and he scored two runs. Crawford was 3-for-5 with two runs. Rodriguez also scored twice.

Trent Grisham hit a two-run homer in the ninth off left-handed Mariners reliever Tommy Milone for the Padres' only runs.

More must-reads:

TODAY'S BEST
Pacers ride historic shooting performance to Game 7 blowout of Knicks
Watch: Aaron Judge blasts 13th home run in Yankees' seventh straight win
Knicks' Jalen Brunson suffers serious injury in Game 7 vs. Pacers
Phil Foden lifts Manchester City to fourth consecutive English Premier League title
Dodgers add recently acquired left-hander to active roster
Report: 2023 No. 7 pick expected to terminate KHL contract, join Flyers
Mavericks advance to Western Conference Finals aided by controversial call late
Connor McDavid, Oilers hammer Canucks to force Game 7
Tyson Fury-Oleksandr Usyk epic increases excitement for potential rematch
Seize the Grey wins in muddy Preakness
Even Mike Budenholzer admits the Suns need a point guard
Watch: Juan Soto's first multi-homer game as a Yankee
Xander Schauffele, Collin Morikawa lead at PGA Championship
Knicks could get major boost for Game 7 showdown with Pacers
Giants All-Star pitcher suffers setback in recovery from injury
Panthers star named winner of 2024 Selke Trophy
WNBA to investigate $100,000 sponsorship deals for Aces players
Tiger Woods blames one big factor for missing the cut at PGA Championship
'Ain't good enough': Draymond Green claims Celtics must 'win it all' or it's a 'failure'
Blue Jays GM wants struggling club to feel 'massive sense of urgency'