Orlando Ramirez-USA TODAY Sports

Jurickson Profar homered on Antonio Senzatela's second pitch of the game to trigger a three-run first and Mike Clevinger held Colorado to one run over seven innings as the San Diego Padres defeated the visiting Rockies 4-1 on Monday.

Clevinger (3-3) gave up five hits and no walks while striking out six. He matched the season high for innings pitched that he established on July 26 against the Detroit Tigers.

On a day when the Padres acquired three-time NL Reliever of the Year Josh Hader from the Milwaukee Brewers in a trade, Luis Garcia got the final two outs to record his second save of the season -- both in the past two days.

The victory, in the opener of a five-game series, was San Diego's third in four games. Colorado lost for the fourth time in five contests.

After Profar hit the third game-opening homer of his career, Manny Machado doubled and Jake Cronenworth drew a walk. Both runners moved up when Luke Voit grounded out to second for the first out of the inning.

Machado scored when Wil Myers grounded out to short. It was Myers' first at-bat since May 31, as he had been out due to a knee injury, and the grounder produced the 500th RBI of his career. Nomar Mazara then singled home Cronenworth to give the Padres a quick 3-0 lead.

By hitting his 12th homer of the season, Profar homered in three straight games for the first time in his career.

The Padres' fourth run came when Trent Grisham homered to left-center field off Carlos Estevez with one out in the seventh. It was the center fielder's 11th homer of the season.

The Rockies' lone run came in the sixth. Jose Iglesias opened the inning with a double on a sharp grounder inside the third base bag. C.J. Cron followed with a single to right, with Iglesias stopping at third. Brendan Rodgers got Iglesias home on a sacrifice fly to right before Clevinger struck out Randal Grichuk and Ryan McMahon.

Senzatela (3-6) gave up three runs on five hits and three walks with five strikeouts in six innings.

More must-reads:

TODAY'S BEST
Watch: Stars, Golden Knights trade goals in first period of Game 5
Watch: Heat can't figure out how to stop Celtics star
Dolphins owner turns down multibillion-dollar offer for control of team
Analyst highlights concerns about Vikings QB J.J. McCarthy
Bucks release concerning injury report as Game 6 looms
Five-time NBA All-Star reveals thoughts on retirement amid rumors
Report: Hurricanes pull extension offer for HC Rod Brind'Amour
Bears GM discusses if he considered trading Caleb Williams pick
MLB hands out multiple suspensions for Rays-Brewers brawl
Insider predicts when Giants QB Daniel Jones could lose starting job
Brittney Griner opens up on arrest, imprisonment in Russia
Saints to sign veteran DB
Celtics provide updated timeline on Kristaps Porzingis injury
Recruit reveals pitch he received from John Calipari
Draft expert thinks unheralded Western Michigan DE is a steal for Cowboys
NHL announces 2024 Norris Trophy finalists
Former Yankees infielder rips team after loss to Orioles
Lightning reportedly extend HC Jon Cooper
Watch: Tyrese Maxey saves Sixers' season with two huge shots
Hurricanes eliminate Islanders with help of third-period rapid-fire goals

Want more MLB news?

Join the hundreds of thousands of fans who start their day with Yardbarker's Morning Bark, the best newsletter in sports.