Orioles right fielder Trey Mancini (16) tips his helmet during his first inning at-bat against the Boston Red Sox at Oriole Park at Camden Yards.  Tommy Gilligan-USA TODAY Sports

Trey Mancini had a memorable afternoon at the Baltimore Orioles’ home opener on Thursday.

Mancini was playing his first game at Oriole Park at Camden Yards since he was diagnosed with stage 3 colon cancer last March. Mancini missed the 2020 season, but he was declared cancer-free in November and was able to return in 2021.

Mancini was recognized with a huge standing ovation from Orioles fans in pregame introductions as well as before his first at-bat against the Boston Red Sox. Even Red Sox players joined in the applause.

Mancini had huge support from his teammates and fans during his cancer battle. It was great to see everyone take the opportunity to applaud him as he made his successful return to baseball.

Mancini hit .291 with 35 home runs in his last full season in 2019.

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