San Francisco 49ers tight end George Kittle won't suit up in Week 3. Pool Photo-USA TODAY Sports

49ers All-Pro TE George Kittle (knee) won't play vs. Giants

San Francisco 49ers All-Pro tight end George Kittle won't make his return to action against the New York Giants at MetLife Stadium on Sunday. 

Hours after San Francisco head coach Kyle Shanahan announced that quarterback Nick Mullens will start under center as Jimmy Garoppolo recovers from the sprained ankle he suffered while facing the New York Jets last weekend, Shanahan ruled Kittle out with the knee injury that has sidelined him for the better part of the past two weeks. 

Kittle, 26, tweaked his knee in the first half of the Week 1 loss to the Arizona Cardinals. While Kittle remained on the field throughout the last two quarters of that game, Garoppolo didn't target him once after halftime. 

Kittle will have plenty of company on the list of 49ers players unavailable to face Big Blue: 

2019 Defensive Rookie of the Year Nick Bosa and fellow defensive lineman Solomon Thomas are both out for the year due to the torn ACLs they sustained against the Jets. San Francisco was hoping the extra week off would allow Kittle to see at least a limited number of snaps against the Giants, but Shanahan and his staff may have decided that one of the best players at his position shouldn't test a knee injury on the same MetLife turf that was rather unkind to the 49ers on Sept. 20. 

More must-reads:

TODAY'S BEST
Lando Norris wins Miami Grand Prix for his first career F1 victory
Rangers hold off late Hurricanes rally to take early series lead
Watch: Shohei Ohtani homers twice as Dodgers sweep Braves
Taylor Pendrith outlasts Ben Kohles at Byron Nelson for maiden win
Watch: Astros woes continue in one-run loss to Mariners
Panthers star throws some shade at defeated Maple Leafs
Donovan Mitchell channeled 'The Answer' in first-round win vs. Magic
NASCAR Cup Series race at Kansas delayed
Watch: Juan Soto's three-run double gives Yankees 5-2 lead over Tigers in seventh
Pirates GM responds to calls to promote ace pitching prospect
Dodgers place right-hander on 15-day injured list
Liverpool forward Mohamed Salah joins elite company in victory vs. Tottenham
Former All-Pro CB medically cleared for football activities
NHL announces 2024 Selke Trophy finalists
J.J. Watt has interesting comments on possibility of playing in 2024
Russell Westbrook reacts to reports of him leaving Clippers
Ant-Man leads Timberwolves to Game 1 upset of Nuggets
Luis Arraez makes history in Padres debut
Corey Heim dominates Truck Series race at Kansas Speedway while tempers flare on pit road
Lionel Messi sets MLS record with monster game