San Francisco 49ers offensive tackle Trent Williams. Darren Yamashita-USA TODAY Sports

The San Francisco 49ers will be without star offensive lineman Trent Williams for at least a few weeks after he suffered an injury Sunday against the Denver Broncos.

49ers coach Kyle Shanahan said Monday that Williams suffered a high ankle sprain and will miss at least a few weeks, potentially anywhere from four-to-six.

This certainly comes as a major blow to the 49ers on the heels of a disappointing loss that dropped them to 1-2. Williams, a first-team All-Pro in 2021, is the anchor of the San Francisco offensive line, and his absence will be significant.

The 49ers are facing an uphill climb with as many injuries as they are dealing with. Williams going down will probably make it even harder for Shanahan to implement anything resembling his desired gameplan.

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