Nick Bosa finished fourth in the NFL with 15.5 sacks this season. Tim Heitman-USA TODAY Sports

49ers Pro Bowl DE Nick Bosa ruled out vs. Cowboys with concussion

The San Francisco 49ers held a two-possession lead at 16-7 heading into halftime of their NFC wild-card game against the Dallas Cowboys on Sunday. If the Niners were to hold on, they would become the first road team to win during wild-card weekend thus far, as the Las Vegas Raiders, New England Patriots and Philadelphia Eagles all came up short in their respective road bouts.

However, San Francisco found out early in the third quarter that it would have to play the rest of the game without arguably its best defender.

Bosa -- a two-time Pro Bowler who finished fourth in the NFL in sacks (15.5) during the regular season -- took a "blow to the head" late in the first half per ESPN NFL reporter Nick Wagoner and didn't join his teammates on the sideline after intermission. Bosa tied Pittsburgh Steelers superstar T.J. Watt for the NFL lead in tackles for loss with 21 during the regular season as well.

The 24-year-old former second overall pick is in his third NFL season.

More must-reads:

TODAY'S BEST
Why the Wizards made the right hiring with HC Brian Keefe
Oilers rally from early deficit to beat Stars, tie WCF
Another masterpiece by Paul Skenes caps remarkable calendar year for rookie phenom
Bengals HC Zac Taylor addresses holdouts from pair of star receivers
Scott Boras makes telling comments on future of Yankees' Juan Soto
Star Arizona guard makes huge decision on NBA Draft status
Iga Swiatek, Naomi Osaka have opposite reactions to crowd following epic French Open match
Kyrie Irving praises Karl-Anthony Towns for overcoming 'unfair criticism' in Game 4
Watch: Minnesota wins inaugural PWHL Walter Cup
Mets outfielder reveals details of team meeting following latest lopsided loss
Mavericks provide notable status update on star rookie ahead of Game 5
Watch: Benches clear after Giants buzz Bryce Harper
Wizards make decision on their new head coach
Veteran sportscaster gives valuable insight into Caitlin Clark's WNBA debut
Patriots QB Jacoby Brissett addresses 'elephant in the room'
AEW owner stays quiet on potential interest in top WWE star
Donovan Mitchell's influence on Cavaliers listed among 'most powerful' in the NBA
Clippers 'determined' to keep these two star free agents
AEW sustains another major injury blow after Double or Nothing
Celtics HC Joe Mazzulla offers update on Kristaps Porzingis ahead of NBA Finals