Trey Lance (5) gets the starting nod after Jimmy Garoppolo (10) was ruled out with a calf injury. Kyle Terada-USA TODAY Sports

49ers QB Jimmy Garoppolo ruled out; Trey Lance to start at Cardinals

San Francisco 49ers starting quarterback Jimmy Garoppolo has been ruled out for Sunday's showdown with the undefeated Arizona Cardinals because of the calf contusion he suffered in last Sunday's loss to the Seattle Seahawks that dropped the Niners to 2-2, according to Ian Rapoport of NFL Network. 

Rookie and third overall pick Trey Lance will make his first career start. Whether or not Garoppolo returns to the lineup when he's healthy will have to be seen. 

Lance completed 50% (9-of-18) of his pass attempts for 157 yards and two touchdowns in the defeat to Seattle, and he added 41 rushing yards on seven carries. 

San Francisco head coach Kyle Shanahan has repeatedly said since the spring he planned to start a healthy Garoppolo over Lance so that the first-year pro could learn about life in the NFL from the sidelines, and the 49ers have a bye week before they return to action against the Indianapolis Colts on Oct. 24. 

Of course, Chicago Bears head coach Matt Nagy made similar statements about veteran Andy Dalton and rookie Justin Fields earlier this year before Dalton went down to a knee injury last month. 

Nagy named Fields his QB1 moving forward on Wednesday. 

More must-reads:

TODAY'S BEST
Chiefs move on from young running back
20-year MLB veteran working out, unsure about playing future
USA Hockey names HC for 2025 4 Nations Face-Off and 2026 Olympics
Key Knicks forward ruled out for Game 7 vs. Pacers
Pacers' Pascal Siakam leads team to Game 6 win vs. Knicks
Watch: Matt Duchene's 2OT winner sends Stars to conference final
Scottie Scheffler shoots improbable 66 after warming up for PGA Championship in a jail cell
Report: Tua Tagovailoa away from Dolphins amid contract chatter
Nuggets star has worrying comment about latest injury
Paul Skenes makes incredible Wrigley Field history in second-career MLB start
Giants rookie CF to undergo season-ending labrum surgery
Yankees' Juan Soto reacts to Hal Steinbrenner contract talk
Late goal sends Panthers to Eastern Conference Finals
Ex-teammate of Shohei Ohtani placed bets with same illegal bookmaker as interpreter 
Former Rams first-round pick retires from NFL after 11 seasons
Insider provides major injury update on Celtics' Kristaps Porzingis
Watch: Bruins strike first in Game 6 with incredible backhand goal
Dodgers make series of moves involving notable players
Hurricanes not expected to re-sign defenseman, center
Maple Leafs tab former Stanley Cup winner as new head coach