Maria Lysaker-USA TODAY Sports

The San Francisco 49ers have lost a running back. The Denver Broncos announced they have signed Marlon Mack from the Niners' practice squad to their active roster.

San Francisco signed Mack to the practice squad on September 14. He has been active for two games since, including the 49ers' Week 3 contest against the Broncos. Mack was also active the next week against the Los Angeles Rams.

The Indianapolis Colts made Mack a fourth-round draft pick in 2017. He has registered 2,484 rushing yards and 20 touchdowns in his six NFL seasons while adding 57 receptions for 448 yards and two receiving touchdowns.

Mack's best statistical season came with the Colts in 2019, when he recorded 1,091 rushing yards and eight touchdowns on 247 carries. That followed a 2018 campaign where he carried the ball 195 times for 908 yards and nine rushing scores.

Mack has appeared in only eight games since suffering a torn Achilles during Week 1 of the 2020 season.

More must-reads:

TODAY'S BEST
Veteran WR announces retirement from NFL
Mavericks come from behind to down Thunder, take 2-1 series lead
Stars continue road dominance with Game 3 win over Avalanche
Watch: Paul Skenes wastes no time showing why Pirates drafted him No. 1 overall
Watch: Braves were one out away from first no-hitter in 30 years
Roman Wilson hopes to become Steelers' next 'great' WR
Chargers sign veteran edge-rusher
Justin Allgaier dominates at Darlington for first win of 2024
'Great mind': One-time NBA champion endorses candidate for Lakers HC job
Celtics respond with impressive road win vs. Cavaliers in Game 3
Hurricanes' power play finally comes through with season on the line
Watch: An outstanding first half by Donovan Mitchell keeps the Cavaliers alive in Game 3 vs. Celtics
Tigers lose veteran starting pitcher to injury
Watch: Minor league baseball game interrupted by turtle delay
Paul Skenes experiences the Pirates' incompetence in just one game
Rangers ace continues to be plagued by nerve irritation in thumb
Cowboys hint at timeline for extension talks with offensive star
Steelers first-round pick has already 'apologized' to new locker mate
Former Packers WR makes bold prediction about Jordan Love
Broncos release former Super Bowl champion WR