Christian McCaffrey's availability for this week's game is in doubt. Denny Medley-USA TODAY Sports

Previously slated to return in Week 14, Christian McCaffrey has run into another setback. The All-Pro Panthers running back suffered a quadriceps injury during the team’s bye week, and Matt Rhule said it tightened up during Wednesday’s practice, David Newton of ESPN.com notes

Rhule pointed to an offsite workout for the cause of McCaffrey’s latest malady, per Joe Person of The Athletic. A high-ankle sprain and a shoulder ailment have limited McCaffrey to just three games this season. Rhule said earlier this week McCaffrey was set to play against the Broncos on Sunday. This latest update could change that status. 

Given McCaffrey’s long-term importance to the Panthers, it would not exactly surprise at this juncture if the team opted to hold him out for the rest of the season. But it is too early to tell on that front, and Rhule said Wednesday that McCaffrey wants to return as soon as possible.

Here is the latest from the NFC South:

  • The Panthers placed eight players on their reserve/COVID-19 list this week after two tested positive for the coronavirus. This appears to have stemmed from an outside gathering of players, with NFL chief medical officer Dr. Allen Sills indicating a bye-week gathering led to the virus cases, via Person. Seven of those players — including starters Shaq Thompson, D.J. Moore, Curtis Samuel and Derrick Brown — remain on Carolina’s COVID list.
  • Antonio Brown should be in the clear on finishing the 2020 season, and a recent change for his civil trial date could affect his 2021 free agency. A Florida judge moved the Buccaneers wide receiver’s trial date — for a civil case stemming from Britney Taylor’s rape allegation — to Dec. 6, 2021, per Tom Pelissero of NFL.com. The NFL suspended Brown eight games this season, but Taylor’s allegation did not factor into that ban. The Taylor suit threatens to lead to another Brown ban, but that issue will be tabled for a while.
  • Tom Brady's assimilation to Bruce Arians' offense has not gone especially smoothly, despite the future Hall of Famer’s sporadic success in his first Bucs season. Particularly, the bevy of deep passes Arians’ offense calls for have resulted in Brady struggling as of late. From Weeks 8-11, Brady was just 5 percent (1-of-19) on passes that traveled 20-plus yards in the air, and ESPN.com’s Jenna Laine notes the Bucs staff had discussed adjusting the offense before their bye week. Arians said recently that coverage recognition, and not ability, contributed more to Brady’s deep-ball issues. It will be interesting to see if the staff made larger-scale changes to the offense during the bye, considering Brady’s penchant for quick-strike, shorter passes. The Bucs, who have lost back-to-back games, will face the Vikings on Sunday.
  • The Falcons are set to interview Saints assistant GM Terry Fontenot for their GM post. One of three known candidates to succeed Thomas Dimitroff, Fontenot has been with the Saints for more than 15 years.

More must-reads:

TODAY'S BEST
James Harden sets dreadful playoff record in Game 5 loss
Suns GM faces backlash for bizarre claims about Kevin Durant
Pair of Celtics score 25 points in series-clinching win over Heat
Oilers stars take over in second period to eliminate Kings
Dolphins owner turns down multibillion-dollar offer for control of team
MLB hands out multiple suspensions for Rays-Brewers brawl
Deion Sanders enters social media fray after criticism from former player
Cubs' Shota Imanaga joins impressive club after another incredible outing
Report: Hurricanes pull extension offer for HC Rod Brind'Amour
Knicks legend rips 76ers' Joel Embiid for 'crying too much'
Falcons' Jessie Bates addresses the team's QB conundrum
Mavericks use big third quarter to pull away from Clippers in Game 5
Stars finally win at home, take series lead over Golden Knights
Watch: Stars, Golden Knights trade goals in first period of Game 5
Watch: Heat can't figure out how to stop Celtics star
Analyst highlights concerns about Vikings QB J.J. McCarthy
Bucks release concerning injury report as Game 6 looms
Five-time NBA All-Star reveals thoughts on retirement amid rumors
Bears GM discusses if he considered trading Caleb Williams pick
Insider predicts when Giants QB Daniel Jones could lose starting job

Want more Panthers news?

Join the hundreds of thousands of fans who start their day with Yardbarker's Morning Bark, the best newsletter in sports.