Trevor Ruszkowski-USA TODAY Sports

The Colts will be without their entire interior offensive line Saturday. After they ruled out Ryan Kelly and Mark Glowinski, the Colts placed Quenton Nelson on their reserve/COVID-19 list.

A three-time All-Pro, Nelson is Indianapolis’ top offensive lineman and arguably the NFL’s premier guard. But, after Glowinski’s positive coronavirus test, Nelson will not be with the team in Arizona, either.

Indianapolis has dealt with availability issues across its O-line this season, but this will be a task for Carson Wentz, Jonathan Taylor and Co. Nelson did miss three games earlier this year, and he underwent foot surgery during training camp. But the former top-10 pick came back in Week 7 and had not missed any time since. Nelson became a four-time Pro Bowler this week and is on track toward a record-setting guard extension in 2022.

FiveThirtyEight.com pegs the Colts’ playoff chances at 89% going into Week 16, but the 8-6 team’s depth will be tested. The Colts used Chris Reed in place of Nelson earlier this season. If Nelson is unvaccinated, he would miss the Colts’ Week 17 game — against the Raiders — as well. Nelson was unvaccinated going into the season, having been a close contact before Week 1.

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