Indianapolis Colts strong safety Khari Willis. Kirby Lee-USA TODAY Sports

A Colts starting safety for most of the past three seasons, Khari Willis informed the team he will retire from the NFL. Willis intends to pursue a ministry career, he said on Instagram.

The Colts had excused Willis from their minicamp last week, and he had also missed their OTAs. Willis, who became eligible for a contract extension in January, will walk away from the league after just three seasons.

This represents a blow to the Colts’ defense. Willis, 26, had started 33 of the 39 career games he played. After breaking into Indianapolis’ starting lineup as a rookie, he was a first-string regular over the past two seasons. He intercepted four career passes, including two last season, and made 219 career tackles.

The Colts traded up for Willis in the 2019 fourth round, and he teamed with Julian Blackmon as the team’s primary safeties over the past two seasons. Blackmon missed 11 games last season, suffering an Achilles tear. Willis played through injury issues, but an IR stint and a COVID-19-related absence limited him to 11 games in 2021. Calf and knee trouble led Willis to IR last season. He missed time due to a concussion and broken ribs in 2020.

Indianapolis has been active at safety this offseason. The team traded up in the third round to select Maryland safety Nick Cross. That move came after the Colts signed longtime Eagles starter Rodney McLeod. Indianapolis also added ex-Kansas City backup safety Armani Watts earlier this year. Cross should be expected to team with Blackmon in the long-term, though Joel Erickson of the Indianapolis Star notes McLeod may get the call to start this season as Cross develops.

More must-reads:

TODAY'S BEST
Chiefs move on from young running back
20-year MLB veteran working out, unsure about playing future
USA Hockey names HC for 2025 4 Nations Face-Off and 2026 Olympics
Key Knicks forward ruled out for Game 7 vs. Pacers
Pacers' Pascal Siakam leads team to Game 6 win vs. Knicks
Watch: Matt Duchene's 2OT winner sends Stars to conference final
Scottie Scheffler shoots improbable 66 after warming up for PGA Championship in a jail cell
Report: Tua Tagovailoa away from Dolphins amid contract chatter
Nuggets star has worrying comment about latest injury
Paul Skenes makes incredible Wrigley Field history in second-career MLB start
Giants rookie CF to undergo season-ending labrum surgery
Yankees' Juan Soto reacts to Hal Steinbrenner contract talk
Late goal sends Panthers to Eastern Conference Finals
Ex-teammate of Shohei Ohtani placed bets with same illegal bookmaker as interpreter 
Former Rams first-round pick retires from NFL after 11 seasons
Insider provides major injury update on Celtics' Kristaps Porzingis
Watch: Bruins strike first in Game 6 with incredible backhand goal
Dodgers make series of moves involving notable players
Hurricanes not expected to re-sign defenseman, center
Maple Leafs tab former Stanley Cup winner as new head coach