Philadelphia used DeSean Jackson as a punt returner during the fourth quarter Thursday night, and that's when he injured his leg. Bill Streicher-USA TODAY Sports

Eagles' DeSean Jackson being placed on injured reserve, ruled out indefinitely

Alshon Jeffery will be welcoming DeSean Jackson to the sideline, and it could be for the rest of the season.

Jackson missed weeks four to six with a hamstring injury, and now he's being placed on injured reserve after suffering an ankle injury against the New York Giants on Thursday night, according to NFL Network's Ian Rapoport. He'll be out indefinitely, although he could return at some point during the season. 

The 33-year-old had a 12-yard run and caught three passes for 34 yards against the Giants. Philadelphia used him as a punt returner during the fourth quarter, and that's when he injured his leg. Jackson had to be helped off the field, putting no weight on his right leg. He was carted off the sideline after examination in the medical tent.

Jackson took an initial hit from Madre Harper, who was handed a 15-yard penalty for lowering his helmet to initiate contact. The second hit from Corey Ballentine is the one that hurt Jackson's leg.

Carson Wentz now will officially rely on Travis Fulgham, J.J. Arcega-Whiteside and John Hightower for the remainder of the season.

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