Jason Bean / USA TODAY NETWORK

O.J. Simpson, a Pro Football Hall of Fame running back who was accused of, and ultimately acquitted, in the 1994 killings of his former wife and her friend in the "trial of the century," has died after a battle with cancer. He was 76.

Simpson died Wednesday, his family announced on social media.

"On April 10th, our father, Orenthal James Simpson, succumbed to his battle with cancer," the family wrote on Simpson's official X (formerly Twitter) account. "He was surrounded by his children and grandchildren. During this time of transition, his family asks that you please respect their wishes for privacy and grace."

Simpson, a San Francisco native, was an All-American at Southern California. He played for the Buffalo Bills, who drafted him with the No. 1 overall pick in 1969, and was a five-time All-Pro in his nine seasons there. He concluded his career with two seasons as a member of the 49ers, then transitioned to a career as a commercial pitchman and broadcaster before his arrest.

More must-reads:

TODAY'S BEST
Report: 2023 No. 7 pick expected to terminate KHL contract, join Flyers
Mavericks advance to Western Conference Finals aided by controversial call late
Connor McDavid, Oilers hammer Canucks to force Game 7
Tyson Fury-Oleksandr Usyk epic increases excitement for potential rematch
Seize the Grey wins in muddy Preakness
Even Mike Budenholzer admits the Suns need a point guard
Watch: Juan Soto's first multi-homer game as a Yankee
Xander Schauffele, Collin Morikawa lead at PGA Championship
Knicks could get major boost for Game 7 showdown with Pacers
Giants All-Star pitcher suffers setback in recovery from injury
Panthers star named winner of 2024 Selke Trophy
WNBA to investigate $100,000 sponsorship deals for Aces players
Tiger Woods blames one big factor for missing the cut at PGA Championship
'Ain't good enough': Draymond Green claims Celtics must 'win it all' or it's a 'failure'
Blue Jays GM wants struggling club to feel 'massive sense of urgency'
Raptors expected to flip former NBA champion during the offseason
MLB insider reveals Mets' massive extension offer that Pete Alonso turned down
Celtics legend provides update after gruesome finger injury
Bulls hire former NBA head coach as top assistant
Chiefs move on from young running back

Want more sports news?

Join the hundreds of thousands of fans who start their day with Yardbarker's Morning Bark, the best newsletter in sports.