Charles LeClaire-USA TODAY Sports

Fresh off the best rushing game of his career, Detroit Lions third-year running back D'Andre Swift missed Wednesday's practice with an ankle injury.

In what could be a telling move, the Lions signed running back Justin Jackson to the active roster from the practice squad.

Swift, 23, rushed for a career-high 144 yards in Sunday's loss to the Philadelphia Eagles. He averaged 9.6 yards per carry and scored a touchdown. He also caught three passes for 31 yards. It's unclear when or how Swift was injured. He played 67 percent of Detroit's offensive snaps.

Jamaal Williams is the No. 2 running back. He rushed 11 times for 28 yards and two touchdowns against the Eagles.

Jackson was on the active roster for Week 1 and played 20 snaps on special teams. He has 1,040 career rushing yards and four touchdowns in 43 games (seven starts) with the Los Angeles Chargers.

Also, Lions center Frank Ragnow (groin) and left tackle Taylor Decker (undisclosed) missed practice Wednesday. Halapoulivaati Vaitai is already on injured reserve and backup guard Tommy Kraemer (back) remains out.

"Frank's a little sore," Lions coach Dan Campbell said Wednesday. "He won't practice today, so we're just going to monitor him and see how he feels. It is, it's kind of a day-to-day, and see where we go with it."

The team also re-signed tackle Darrin Paulo to the practice squad.

More must-reads:

TODAY'S BEST
Phil Foden lifts Manchester City to fourth consecutive English Premier League title
Dodgers add recently acquired left-hander to active roster
Report: 2023 No. 7 pick expected to terminate KHL contract, join Flyers
Mavericks advance to Western Conference Finals aided by controversial call late
Connor McDavid, Oilers hammer Canucks to force Game 7
Tyson Fury-Oleksandr Usyk epic increases excitement for potential rematch
Seize the Grey wins in muddy Preakness
Even Mike Budenholzer admits the Suns need a point guard
Watch: Juan Soto's first multi-homer game as a Yankee
Xander Schauffele, Collin Morikawa lead at PGA Championship
Knicks could get major boost for Game 7 showdown with Pacers
Giants All-Star pitcher suffers setback in recovery from injury
Panthers star named winner of 2024 Selke Trophy
WNBA to investigate $100,000 sponsorship deals for Aces players
Tiger Woods blames one big factor for missing the cut at PGA Championship
'Ain't good enough': Draymond Green claims Celtics must 'win it all' or it's a 'failure'
Blue Jays GM wants struggling club to feel 'massive sense of urgency'
Raptors expected to flip former NBA champion during the offseason
MLB insider reveals Mets' massive extension offer that Pete Alonso turned down
Celtics legend provides update after gruesome finger injury

Want more Lions news?

Join the hundreds of thousands of fans who start their day with Yardbarker's Morning Bark, the best newsletter in sports.