Jeffrey Becker-USA TODAY Sports

Wide receiver Amon-Ra St. Brown has been ruled out for the Detroit Lions' game against the visiting Seattle Seahawks on Sunday.

Lions head coach Dan Campbell on Friday announced the playing status on St. Brown, who has been held out of practice this week after sustaining an ankle injury in last Sunday's 28-24 setback to the Minnesota Vikings.

Wideouts Josh Reynolds and DJ Chark will look to pick up the slack in place of the 22-year-old St. Brown, who leads the team in catches (23), receiving yards (253) and receiving touchdowns (three).

Running back D'Andre Swift, 23, likely will miss Sunday's game against the Seahawks with a shoulder injury, Campbell said.

Jamaal Williams stepped into the lead role last season after Swift sustained a shoulder sprain in December.

Williams had 20 carries for 87 yards and two touchdowns versus the Vikings. He leads the team with four rushing TDs.

Swift is averaging 8.6 yards per carry in three starts this season, totaling 231 yards, good for eighth in the NFL.

Williams has a team-leading 43 carries for 168 yards.

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