Indianapolis Colts quarterback Carson Wentz Robert Scheer/IndyStar / USA TODAY NETWORK

A change to the NFL’s COVID-19 protocols could have a huge impact on the Indianapolis Colts-Las Vegas Raiders game in Week 17.

The CDC released new guidelines for the COVID-19 pandemic on Monday. Among the biggest changes is that those who test positive for COVID — vaccinated or unvaccinated — now only have to quarantine for five days if they are free of symptoms after that time. Previously, the minimum quarantine was 10 days. According to ESPN’s Adam Schefter, the NFL is expected to adopt those new guidelines and could reach an agreement with the NFL Players Association on Tuesday.

Wentz landed on the COVID list on Tuesday. If he only needs to quarantine for five days, he could be cleared in time for Sunday if he has no symptoms.

That would be huge for the Colts, who can clinch a playoff berth with a win over the Raiders. They still have a strong chance of making the postseason even if they lose, but the game is crucial for seeding in the AFC.

The Colts are reportedly exploring a big contingency plan with Wentz possibly out. If all goes well, they may not need it.

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