A knee injury will sideline Alvin Kamara this weekend. Chuck Cook-USA TODAY Sports

Alvin Kamara will miss his first game this season. The Saints will hold their top skill-position player out against the Titans because of a knee sprain.

The fifth-year running back has not been especially injury-prone during his career, having missed just four games in his previous four seasons. But Kamara has missed at least one contest in each of the past three seasons.

New Orleans reacquiring Mark Ingram via trade looms larger now. Ingram has played around 30% of the Saints’ offensive snaps in his two games back with the team. He has logged 15 carries in that span. The 11th-year veteran is also on track to break the team’s career rushing record, a mark Deuce McAllister holds with 6,096 yards, in Tennessee. Ingram is 20 yards away from eclipsing McAllister’s Saints standard.

Kamara, whose 21 touchdowns led the NFL last season, is 4-of-4 in Pro Bowls. Kamara’s 840 scrimmage yards through eight games had him on track for a career-best number here, but his absence this week will affect that pace. His loss certainly will sting a Saints team that is set to start Trevor Siemian for a second straight week and also missing Michael Thomas. The sixth-year wideout is out for the season. New Orleans was among the many teams that failed in a bid to sign Odell Beckham Jr. this week.

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