USA TODAY Sports

The Pittsburgh Steelers could be without two offensive line starters against the New England Patriots, as they've ruled both center Mason Cole and guard Isaac Seumalo questionable for Week 14. 

Seumalo left Week 13 with a shoulder injury and missed the team's only full practice. He was limited in walk-through. The Steelers will make him a game-time decision, but after getting limited work during a short week, it's not optimistic he'll be available. 

Cole popped up on the team's injury report earlier in the week with a neck injury. He was limited during both days of practice but is also questionable heading into the game. 

If both Cole and Seumalo are unavailable, the Steelers will turn to Nate Herbig and Spencer Anderson as their starters. Both players have experience playing guard and center, but Herbig would likely replace Cole while Anderson fills in at left guard. 

On the Steelers' depth chart, Anderson is Seumalo's backup, while Herbig is listed as the backup center. 

The Steelers would likely also elevate an offensive lineman from the practice squad to add depth on the interior. 

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