Denny Simmons / The Tennessean / USA TODAY NETWORK

Pittsburgh Steelers linebacker Cole Holcomb was carted off the field with a left knee injury during the first quarter of Thursday's contest against the Tennessee Titans.

The Steelers quickly ruled Holcomb out for the rest of the game.

Holcomb was injured while chasing after Tennessee's DeAndre Hopkins on a 29-yard gain late in the opening quarter. Pittsburgh safety Keanu Neal also was in pursuit and his left leg slammed into Holcomb's leg as he passed by.

Holcomb's leg bent awkwardly after the contact. He immediately grabbed for his left knee after falling to the ground.

Holcomb is in his first season with the Steelers after spending his first four NFL seasons with the Washington Commanders. He had 52 tackles and two forced fumbles entering the contest.

More must-reads:

TODAY'S BEST
Timberwolves mount incredible second-half comeback to stun Nuggets in Game 7
Watch: NASCAR drivers exchange punches after crash in All-Star Race
Knicks star offers passionate defense of HC Tom Thibodeau after Game 7 loss
Xander Schauffele proves doubters wrong with historic win at 2024 PGA Championship
Canucks won't have linchpin forward for Game 7 vs. Oilers
Pacers ride historic shooting performance to Game 7 blowout of Knicks
Watch: Aaron Judge blasts 13th home run in Yankees' seventh straight win
Knicks' Jalen Brunson suffers serious injury in Game 7 vs. Pacers
Phil Foden lifts Manchester City to fourth consecutive English Premier League title
Dodgers add recently acquired left-hander to active roster
Report: 2023 No. 7 pick expected to terminate KHL contract, join Flyers
Mavericks advance to Western Conference Finals aided by controversial call late
Connor McDavid, Oilers hammer Canucks to force Game 7
Tyson Fury-Oleksandr Usyk epic increases excitement for potential rematch
Seize the Grey wins in muddy Preakness
Even Mike Budenholzer admits the Suns need a point guard
Watch: Juan Soto's first multi-homer game as a Yankee
Xander Schauffele, Collin Morikawa lead at PGA Championship
Knicks could get major boost for Game 7 showdown with Pacers
Giants All-Star pitcher suffers setback in recovery from injury