Gary A. Vasquez-USA TODAY Sports

Nathan MacKinnon had two goals, including the game-winner with 45 seconds left in overtime, and an assist as the Colorado Avalanche won their franchise-record 10th straight road game by beating the Anaheim Ducks 5-4 on Sunday.

MacKinnon's power-play goal in overtime followed his game-tying power-play goal with 4:32 left in regulation for the Avalanche, who rallied from a 4-2 third-period deficit.

Mikko Rantanen had two goals and two assists and J.T. Compher also scored for the Avalanche (49-24-6, 104 points), who won for the 14th time in their past 16 games. Pavel Francouz made 19 saves for Colorado.

Devon Toews had three assists and Valeri Nichushkin had two for Colorado, which moved two points ahead of the Dallas Stars (44-21-14, 102 points) atop the Central Division. Colorado is four points ahead of the Minnesota Wild (45-24-10, 100 points), as each team has three regular-season games remaining.

Frank Vatrano had two goals and Adam Henrique and Brett Leason also scored for Anaheim (23-45-12, 58 points), which extended its losing streak to a franchise-record 11 games (0-9-2).

Vatrano broke a 2-2 tie after getting a pass from Troy Terry near the blue line and wristing a low shot that bounced off Francouz and the post before finding the back of the net at the 5:18 mark of the third period. Kevin Shattenkirk also assisted on the play.

The Ducks extended their advantage to 4-2 just over two minutes later when Leason scored off assists from Derek Grant and Jayson Megna at the 7:25 mark.

Rantanen's power-play goal off assists from MacKinnon and Toews pulled Colorado to within 4-3 with 7:51 to go.

The Avalanche took a 2-0 lead at the 13:58 mark of the second period when Rantanen scored off assists from Samuel Girard and Toews.

The Ducks halved the deficit when Vatrano scored off assists from Trevor Zegras and Ryan Strome at the 15:15 mark.

Anaheim tied the game on Henrique's breakaway goal off an assist from Cam Fowler with 1:51 left in the second period.

The Avalanche took a 1-0 lead at the 10:15 mark of the first period when Compher scored off assists from Nichushkin and Erik Johnson.

More must-reads:

TODAY'S BEST
Pacers' Pascal Siakam leads team to Game 6 win vs. Knicks
Watch: Matt Duchene's 2OT winner sends Stars to conference final
Scottie Scheffler shoots improbable 66 after warming up for PGA Championship in a jail cell
Report: Tua Tagovailoa away from Dolphins amid contract chatter
Nuggets star has worrying comment about latest injury
Paul Skenes makes incredible Wrigley Field history in second-career MLB start
Giants rookie CF to undergo season-ending labrum surgery
Yankees' Juan Soto reacts to Hal Steinbrenner contract talk
Late goal sends Panthers to Eastern Conference Finals
Ex-teammate of Shohei Ohtani placed bets with same illegal bookmaker as interpreter 
Former Rams first-round pick retires from NFL after 11 seasons
Insider provides major injury update on Celtics' Kristaps Porzingis
Watch: Bruins strike first in Game 6 with incredible backhand goal
Dodgers make series of moves involving notable players
Hurricanes not expected to re-sign defenseman, center
Maple Leafs tab former Stanley Cup winner as new head coach
NFL insider expands on competition between Steelers QBs Russell Wilson, Justin Fields
NFL sets outrageous prices for Eagles-Packers Brazil game
Broncos 'very unlikely' to bring back former NFL interceptions leader
Greg Olsen offers broadcasting advice to Tom Brady