Olivier Giroud, Rafael Leao and Christian Pulisic are set to start for Milan against Slavia Praha, but Tijjani Reijnders is expected to go on the bench again.
It kicks off at 20:00 GMT at the Stadio Meazza in San Siro, the first leg of the Europa League Round of 16.
The Rossoneri must cope without the injured Tommaso Pobega, plus Mattia Caldara and Jan-Carlo Simic, who are not on the UEFA list.
Milan coach Stefano Pioli is expected to pick the same formation that beat Lazio 1-0 at the Stadio Olimpico this past Friday.
Therefore, Alessandro Florenzi will be confirmed as the starting right-back, Simon Kjaer will get the nod in central defence, and Yacine Adli will partner Ismael Bennacer in the middle of the park leaving Reijnders initially on the bench.
Leao, Pulisic and Ruben Loftus-Cheek will play behind Giroud. The France international and Loftus-Cheek have already won the Europa League in 2018-19 at Chelsea under Maurizio Sarri.
Milan-Slavia Praha, probable line-ups
Milan (4-2-3-1): Maignan; Florenzi, Kjaer, Gabbia, Theo; Adli, Bennacer; Pulisic, Ruben Loftus-Cheek, Leao; Giroud.
Slavia Praha (3-4-2-1): Stanek; Zima, Holes, Vlcek; Doudera, Dorley, Masopust, Boril; Jurecka, Chytil, Schranz.
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