Napoli are without Giovanni Di Lorenzo and Cyril Ngonge against Cagliari, but Victor Osimhen and Piotr Zielinski have recovered.
It kicks off at the Stadio Unipol Domus on Sunday at 14.00 GMT.
The Partenopei made their debut under new coach Francesco Calzona in Wednesday’s 1-1 Champions League Round of 16 draw against Barcelona.
He is their third tactician of the campaign after Rudi Garcia and Walter Mazzarri, so tomorrow will be his first Serie A match in charge of Napoli.
Captain Di Lorenzo is suspended, while January signing Ngonge – who scored the equaliser against Genoa last week – is still not recovered from a muscular issue.
There were some doubts around Osimhen and Zielinski, but both are in the squad and expected to start, especially as the Poland international was cut from the UEFA list and therefore could not participate in the Barcelona match.
Napoli squad for Cagliari: Meret, Gollini, Contini; Mazzocchi, Mario Rui, Natan, Ostigard, Juan Jesus, Rrahmani, Olivera; Anguissa, Cajuste, Zielinski, Dendoncker, Traoré, Lobotka, Lindstrom; Politano, Kvaratskhelia, Simeone, Raspadori, Osimhen
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