Real Betis coach Manuel Pellegrini admits Isco's injury is a blow.
The midfielder is expected to miss six weeks with a hamstring injury.
Pellegrini said: It is a regrettable loss, he had a great time and gave a lot of quality. His personal demands were an example. The injury will last a couple of months, it is not short, he is assimilating it but we are going to recover him physically and emotionally as soon as possible.
"The total deadline will be seen week after week."
He added, We will notice his absence the same, it is transcendental for us. He had a serious injury. But we have to keep an eye on those who are there, this group has known how to go through difficult times without important players.
"We will miss him but we must not justify his injuries but rather improve his position week after week."
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