Real Betis coach Manuel Pellegrini says Isco will see action at Rayo Vallecano.
Isco has been missing for several weeks due to injury.
Pellegrini said: We will talk to the medical staff to see how many minutes we can give him.
"He will be on the list. I see him training with great enthusiasm. From the first day he found out about his injury he tried to recover as soon as possible.
"We have to take him carefully so that he does not have a relapse, but I see him without any fear."
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