Mike Frey-USA TODAY Sports

Mackenzie McDonald knocked out defending champion Rafael Nadal in the second round of the Australian Open on Wednesday (Australia time), rolling to a 6-4, 6-4, 7-5 victory in Melbourne.

Nadal, the tournament's top seed, hadn't exited a Grand Slam event this early since falling in the first round of the 2016 Australian Open. The 36-year-old Spaniard has a men's-record 22 Grand Slam titles, including two last year, the Australian Open and the French Open.

McDonald, a 27-year-old California native, is ranked 65th in the world. He has never reached the quarterfinals of a major tournament in 17 previous attempts. Just to reach the matchup with Nadal, he needed five sets to get past countryman Brandon Nakashima on Monday.

McDonald finished with a 14-6 edge in aces. Each player had 42 winners, but Nadal committed 31 errors while McDonald gave away only 22 points.

"He's an incredible champion," McDonald said of Nadal. "He's never going to give up, regardless of the situation, so even closing it out against a top guy like that is always tough. I kept focusing on myself in the end and got through."

Nadal's loss gives an opening to Serbia's Novak Djokovic to tie for the men's Grand Slam mark. Djokovic has 21 major titles, including last year's Wimbledon crown.

Djokovic, who is seeded fourth, had no trouble in his second-round match at Melbourne on Wednesday, dispatching Spain's Roberto Carballes Baena 6-3, 6-4, 6-0.

More must-reads:

TODAY'S BEST
Mavericks advance to Western Conference Finals aided by controversial call late
Connor McDavid, Oilers hammer Canucks to force Game 7
Tyson Fury-Oleksandr Usyk epic increases excitement for potential rematch
Seize the Grey wins in muddy Preakness
Even Mike Budenholzer admits the Suns need a point guard
Watch: Juan Soto's first multi-homer game as a Yankee
Xander Schauffele, Collin Morikawa lead at PGA Championship
Knicks could get major boost for Game 7 showdown with Pacers
Giants All-Star pitcher suffers setback in recovery from injury
Panthers star named winner of 2024 Selke Trophy
WNBA to investigate $100,000 sponsorship deals for Aces players
Tiger Woods blames one big factor for missing the cut at PGA Championship
'Ain't good enough': Draymond Green claims Celtics must 'win it all' or it's a 'failure'
Blue Jays GM wants struggling club to feel 'massive sense of urgency'
Raptors expected to flip former NBA champion during the offseason
MLB insider reveals Mets' massive extension offer that Pete Alonso turned down
Celtics legend provides update after gruesome finger injury
Bulls hire former NBA head coach as top assistant
Chiefs move on from young running back
20-year MLB veteran working out, unsure about playing future

Want more sports news?

Join the hundreds of thousands of fans who start their day with Yardbarker's Morning Bark, the best newsletter in sports.