Originally written on Queen City Sports  |  Last updated 10/19/14
After a tough loss to the New England Patriots last week, the Bills return to action on Sunday when they take on the San Francisco 49ers. Buffalo enters at 2-2 while the 49ers currently stand at 3-1. For the Bills to win, they’ll have to have one of their best performances of the season as they try to remain in first place in the AFC East.   Ryan Talbot: Bills 27-24 Brandon Hess: 49ers 31-17 The Bills have shown that they have the ability to put a tough loss behind them as they responded well against Kansas City after a tough season opening loss to the NY Jets. Coming off an even more disappointing showing against New England I do believer the Bills will bounce back with a better performance against the Niners. But San Francisco isn’t Kansas City, they are too deep in too many areas for the Bills to pull this one out. The Niners haven’t lost at home to an AFC team in nearly 3 years (Nov. 8th 2009) a streak that should continue for at least another week Mike Straw: 49ers 27-14 The Bills are in a tailspin right now, and I just don’t give them the slightest chance to pull this game out. Mike Bundt: 49ers 24-14 San Francisco has one of the top defenses in the NFL and will make it hard for the Bills to score on Sunday. Look for the 49ers to win a defensive battle.   The post QCS Staff Picks: Bills at 49ers appeared first on Queen City Sports.

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