© Brian Fluharty, USA TODAY

Fresh off of winning AFC Offensive Player of the Week, Buffalo Bills running back James Cook is sitting out of Wednesday's practice due to an undisclosed illness, the team revealed on its injury report.

Cook is one of three Bills out on Wednesday, as linebacker Von Miller (veteran rest) and defensive tackle Jordan Phillips (wrist) also sat out.

What does this mean for Cook's status moving forward?

For starters, the Bills (8-6) are on a short week, as they will have to travel across the country to visit the Los Angeles Chargers (5-9) at SoFi Stadium on Saturday. Buffalo is currently a 12-point favorite, but having Cook fully healthy will be crucial in a must-win game for the Bills.

However, it's only Wednesday and there's no reason to think Cook won't shake off his illness and be ready to play on Saturday,

Cook gashed the Dallas Cowboys in a 31-10 win on Sunday in what was by far the best game of his young two-year NFL career. He rushed 25 times for 179 yards and a touchdown while adding two catches for 42 yards and another score.

More must-reads:

TODAY'S BEST
MLB announces huge news about Pete Rose, 'Shoeless' Joe Jackson
Unfortunate pit road incident with Chase Elliott leaves Chad Knaus unfazed, points to silver lining for the Hendrick driver
Raiders part ways with multiple players, pair of recent draftees
Watch: Myles Turner's dagger stuns top-seeded Cavaliers, seals Pacers' win
Celtics reveal extent of Jayson Tatum's injury
Stars' (other) big trade-deadline addition records hat trick, makes the difference in Game 4 win
Are Bengals, Trey Hendrickson heading toward messy divorce?
Yankees announce severity of Oswaldo Cabrera's injury
Packers set to face defending champion Eagles, dreaded tush push on 'MNF'
Pirates ace to anchor Team USA in 2026 World Baseball Classic
Derek Carr's brother addresses talk of QB potentially playing again
Former Arkansas PG Boogie Fland spurns NBA, but set to be top target in transfer portal
Thunder's Shai Gilgeous-Alexander outduels Nuggets' Nikola Jokic in Game 5 thriller
Signs were there around Dodgers before Roki Sasaki's IL trip
Dodgers to activate future Hall of Famer for season debut
Ravens safety 'to miss most or all of' 2025 season
New update emerges on Steph Curry's injury timeline
Rangers shortstop returns to IL barely a week after previous stint
Will Power fastest in first practice session for 2025 Indianapolis 500
Stars activate key defenseman from LTIR

Want more sports news?

Join the hundreds of thousands of fans who start their day with Yardbarker's Morning Bark, the best newsletter in sports.