Mark J. Rebilas-USA TODAY Sports

The Arizona Cardinals designated running back James Conner to return from injured reserve and opened his 21-day practice window on Wednesday.

Conner sustained a knee injury at the end of a 35-yard run during Arizona's 34-20 loss to the Cincinnati Bengals on Oct. 8. He was placed on IR two days later by the Cardinals, who could welcome both Conner and star quarterback Kyler Murray (torn ACL last season) back to the field for Sunday's game against the visiting Atlanta Falcons.

Conner, 28, has rushed for 364 yards and two touchdowns in five games this year. The two-time Pro Bowl selection is averaging 5.4 yards per carry.

Arizona (1-8) has struggled to ignite its ground attack in his absence. The Cardinals rushed 21 times for just 41 yards in a 27-0 loss to the host Cleveland Browns last Sunday.

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