Giacomo Raspadori and Matteo Politano will start for Napoli against Lazio who will rely on Felipe Anderson, Valentin Castellanos and Gustav Isaksen.
Five Serie A games are scheduled for Sunday, including the big night match between Fiorentina and Inter at the Stadio Franchi.
There is plenty to play for: from the Scudetto to a Champions League placement and the race for survival.
Most clubs in competition to avoid Serie B will play on Sunday.
Genoa host Lecce at 11:30 GMT, while Frosinone visit Hellas Verona and Sassuolo travel to Monza at 14:00.
Lazio and Napoli will meet at the Stadio Olimpico in Rome at 17:00 in search of points for the top four, prior to Fiorentina–Inter.
Napoli coach Walter Mazzarri will confirm a three-man defence with Leo Ostigard joining Amir Rrahmani and Juan Jesus in a three-man backline. Mario Rui and Pasquale Mazzocchi will fight for a spot on the left flank, while Politano and Raspadori will start in attack as Victor Osimhen is on AFCON international duty and Khvicha Kvaratskhelia is suspended.
Two Lazio stars are also banned for Sunday’s meeting, Ciro Immobile and Mattia Zaccagni, so Anderson, Isaksen and Castellanos will start in attack for the Biancocelesti.
Probable Serie A line-ups
Genoa v Lecce
Genoa (3-5-2): Martinez; Vogliacco, Bani, De Winter; Spence, Strootman, Malinovskyi, Thorsby, Vasquez; Retegui, Gudmundsson.
Lecce (4-3-3): Falcone; Gendrey, Pongracci, Baschirotto, Gallo; Kaba, Ramadani, Gonzalez; Almqvist, Kristovic, Oudin.
Monza v Sassuolo
Monza (3-4-2-1): Di Gregorio; Izzo, Pablo Marì, Caldirola; Birindelli, Pessina, Bondo, Ciurria; Colpani, Mota; Djuric.
Sassuolo (4-2-3-1): Consigli; Pedersen, Erlic, Ferrari, Doig; Boloca, Matheus Henrique; Castillejo, Thorstvedt, Laurienté; Pinamonti.
Hellas Verona v Frosinone
Hellas Verona (4-2-3-1): Montipò; Tchatchoua, Dawidowicz, Magnani, Cabal; Serdar, Duda; Suslov, Saponara, Folorunsho; Henry.
Frosinone (4-3-3): Turati; Zortea, Okoli, Romagnoli, Gelli; Mazzitelli, Barrenechea, Brescianini; Soulé, Cheddira, Harroui.
Lazio v Napoli
Lazio (4-3-3): Provedel; Lazzari, Gila, Romagnoli, Marusic; Guendouzi, Rovella, Luis Alberto; Isaksen, Castellanos, Felipe Anderson.
Napoli (3-5-1-1): Gollini; Ostigard, Rrahmani, Juan Jesus; Di Lorenzo, Demme, Lobotka, Zielinski, Mario Rui; Politano, Raspadori.
More must-reads: