San Francisco 49ers wide receiver Deebo Samuel. Cary Edmondson-USA TODAY Sports

Deebo Samuel will miss time for the 49ers, and an update Monday indicated the 2021 All-Pro is dealing with multiple injuries. But the team is expecting him to come back before the regular season ends.

The recently extended wideout/running back moonlighter suffered an MCL sprain and a sprained ankle, Matt Barrows of The Athletic tweets

While the 49ers have encountered extensive trouble with MCL sprains this season, it appears Samuel has run into a fairly mild one.

Kyle Shanahan mentioned Sunday this could be a high ankle sprain, but reports Monday have left the word “high” out of the equation. 

High ankle sprains can linger for several weeks, and the 49ers have seen MCL sprains sideline multiple players for more than a month this year — Elijah Mitchell, Azeez Al-Shaair, Colton McKivitz

Samuel suffering both an MCL sprain and a high ankle issue would seemingly threaten his playoff availability, so it certainly represents good news a regular-season return is expected.

Samuel has a history of major injuries, having suffered a foot fracture during the 2020 offseason and later that year running into multiple bouts of hamstring trouble. 

While 2020 effectively turned into a lost season for Samuel (and other 49ers), he bounced back to play 19 games last season. Samuel, 26, zoomed to All-Pro status in 2021, providing tremendous help to the 49ers’ backfield in addition to his receiving duties. 

The team has not asked quite as much of Samuel in the run game as it did last season, though he did suffer the injury on a carry up the middle. Samuel missed one game due to a hamstring injury this season as well.

The 49ers placed a considerable bet on Samuel this offseason, inking him to a three-year extension worth $71.55M. 

This situation transformed in the team’s favor, after Samuel requested an offseason trade. He returned to the team and is pairing with fellow stars George Kittle and Christian McCaffrey in a rare three-All-Pro skill-position armada. 

Kittle and McCaffrey have extensive injury pasts as well, giving the 49ers risks to manage weekly.

San Francisco has lost Samuel and Jimmy Garoppolo over its past two games. The team is not expected to place Garoppolo on IR, due to the faint hope the veteran passer can return late in the playoffs and its IR situation having become complicated. 

Samuel should not be expected to land on IR, either, given the prospect he could return before the four-game window. The 49ers (9-4) are now up two games on the Seahawks in the NFC West. 

They already routed the surprising contenders in Week 2, when Garoppolo replaced an injured Trey Lance. A win Thursday would effectively lock up the division for San Francisco.

The 49ers also received good news on Brock Purdy, who battled through an oblique injury in Week 14. They are calling the rookie quarterback “day to day.” 

The team did lose defensive lineman Kevin Givens to an MCL sprain; Shahanan said the fourth-year contributor will be out a few weeks. Givens has worked as a starter in place of Javon Kinlaw, who remains on IR. The team has used the former as an 11-game starter this season.

A former UDFA, Givens has remained in the lineup since Arik Armstead‘s recent return. The 49ers are already down D-lineman Hassan Ridgeway; this Givens issue will further thin out their D-line interior. 

The team, which also lost veteran backup cornerback Dontae Johnson to an ACL tear, has maintained its No. 1 defensive ranking despite a spate of injuries. T.Y. McGill remains in the picture at D-tackle, but given the issues affecting Ridgeway and Givens, it should be expected the 49ers will make a move here soon.

More must-reads:

TODAY'S BEST
Historic NCAA settlement reached allowing schools to pay players
Celtics dominate Pacers in Game 2, take 2-0 ECF lead
Cavaliers fire head coach J.B. Bickerstaff
Connor McDavid's 2OT goal gives Oilers win over Stars in Game 1
Rob Manfred hints at big change coming to MLB
Scottie Scheffler arrest case takes another weird turn with new video
QB Russell Wilson believes Steelers can 'do something special'
Pacers star suffers injury in ugly Game 2 loss
Watch: Jaylen Brown's big second quarter lifts Celtics to halftime lead
Broncos HC Sean Payton raves about one QB's progress at OTAs
North Carolina basketball snags instant-impact player via transfer portal
Rams GM shares details about Stetson Bennett’s absence
Perpetual Bulls trade candidate once more hitting the rumor mill
MLB announces host venues for 2026 World Baseball Classic
Knicks marquee trade acquisition could bolt in free agency
Pistons make decision on new president of basketball operations
ESPN and longtime NFL reporter are parting ways
If Lions HC Dan Campbell's assessment of WR is accurate it could mean trouble for opponents
NBA closes investigation into embattled Thunder guard
NFL reporter predicts Cowboys' plan for QB Dak Prescott

Want more sports news?

Join the hundreds of thousands of fans who start their day with Yardbarker's Morning Bark, the best newsletter in sports.