USA TODAY Sports

Now both of the 49ers' starting defensive tackles are injured.

Javon Hargrave left Sunday's win over the Seattle Seahawks with a hamstring injury, according to head coach Kyle Shanahan. The severity of the injury currently is unclear, but if it indeed is a pull, then Hargrave could miss the next few games along with Arik Armstead, who has a knee injury.

Hargrave is having a terrific season with the 49ers. He has 6 sacks, 13 quarterback hits and 40 tackles -- he's been everything the 49ers paid for when they signed him this offseason. He and Armstead form one of the best defensive tackle duos in the NFL, and as long as both are healthy for the playoffs, the 49ers should be fine.

But the 49ers suddenly are the No. 1 seed in the NFC playoff race, so these next few games matter. And in two weeks, they'll have to face the Baltimore Ravens, who are Super Bowl contenders. The 49ers could lose that game if they don't have Hargrave.

If Hargrave and Armstead both miss next week's game against the Arizona Cardinals, the 49ers starting defensive tackles most likely will be Javon Kinlaw and Kevin Givens, who both are starting-caliber players. So the 49ers will be in good hands. But they're losing depth. Those two will need support.

Expect the 49ers to be extremely cautious with Hargrave the next few weeks. Hamstring injuries can get worse if players rush back to action too soon, and the 49ers can't risk losing Hargrave for the playoffs.

More must-reads:

TODAY'S BEST
Historic NCAA settlement reached allowing schools to pay players
Celtics dominate Pacers in Game 2, take 2-0 ECF lead
Cavaliers fire head coach J.B. Bickerstaff
Connor McDavid's 2OT goal gives Oilers win over Stars in Game 1
Rob Manfred hints at big change coming to MLB
Scottie Scheffler arrest case takes another weird turn with new video
QB Russell Wilson believes Steelers can 'do something special'
Pacers star suffers injury in ugly Game 2 loss
Watch: Jaylen Brown's big second quarter lifts Celtics to halftime lead
Broncos HC Sean Payton raves about one QB's progress at OTAs
North Carolina basketball snags instant-impact player via transfer portal
Rams GM shares details about Stetson Bennett’s absence
Perpetual Bulls trade candidate once more hitting the rumor mill
MLB announces host venues for 2026 World Baseball Classic
Knicks marquee trade acquisition could bolt in free agency
Pistons make decision on new president of basketball operations
ESPN and longtime NFL reporter are parting ways
If Lions HC Dan Campbell's assessment of WR is accurate it could mean trouble for opponents
NBA closes investigation into embattled Thunder guard
NFL reporter predicts Cowboys' plan for QB Dak Prescott

Want more 49ers news?

Join the hundreds of thousands of fans who start their day with Yardbarker's Morning Bark, the best newsletter in sports.