Detroit Lions defensive end John Cominsky. Junfu Han/Detroit Free Press / USA TODAY NETWORK

As the Lions’ run of extensions continues with Taylor Decker — and potentially Alim McNeill — they will be without one of their defensive line regulars for an extended stretch. John Cominsky‘s injury at practice Tuesday may sideline him for the entire regular season.

A cart transported Cominsky off the practice field, and ESPN.com’s Adam Schefter reports the veteran D-lineman suffered a torn MCL. This injury is not necessarily a season-ender, but Cominsky is expected to miss months. The playoffs may be the target date, per Schefter. This will be a five- or six-month injury, according to NFL.com’s Ian Rapoport and Mike Garafolo.

This is a setback to a Lions team that played Cominsky on 56 percent of its defensive snaps last season. Initially claimed off waivers — in an interesting transaction, as seven other teams submitted claims for the former Falcon — Cominsky has become a quality piece up front for the Lions. He played 60 percent of the team’s defensive snaps in 2022, rebounding after falling out of favor in Atlanta.

While Pro Football Focus slotted Cominsky 73rd among interior defenders, the advanced metrics site placed him in the top 30 at the position as a run defender. The former fourth-round pick has totaled six sacks and 20 QB hits during his two-season Detroit stay, faring well enough in 2022 to bring the Lions to re-sign him — at two years and $8.5M — last March.

Working more as an interior presence, Cominsky leaves a void for a Lions team that does not yet have D.J. Reader back from the torn quad that ended his 2023 season in Cincinnati. McNeill remains the Lions’ top interior pass rusher, though the team did not see much from third-rounder Brodric Martin during a 28-snap rookie season. Levi Onwuzurike remains on the roster as well. Cominsky, however, trailed only McNeill for snaps by a Lions interior defender. This will require an adjustment for the defending NFC North champs.

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