Clemson at Louisville odds: Opening point spread released

Clemson and Louisville are set for a Friday night showdown in the ACC and the odds have been released. All odds and lines are courtesy of BetMGM.

Clemson and Louisville are coming off games against Florida State and Cal, respectively. Now, they’re ready for the final weeks of the 2025 campaign.

Louisville opened up as a 3.5-point favorite in this game. If you want to bet the over/under, the total was set at 51.5 points.

How to Watch Clemson at Louisville

Time: 7:30 p.m. ET (Friday)
Channel: ESPN
Location: Louisville, Kentucky

While Clemson and Louisville are going in two different directions this season, a lot of talk centered around Tigers’ coach Dabo Swinney. His future is seemingly up in the air, even though most think he won’t leave or be fired by Clemson.

“It would surprise me,” former coach Nick Saban said on College GameDay, in regards to if Swinney would leave Clemson. “In my conversation with him, he never mentioned that. I mean, he was totally focused on what his team needs to do.”

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