College football picks: Week 6 predictions for every Friday game

Today’s college football slate is shaping up to be the best of all the Friday lineups. To sweeten the pot, our expert betting dashboard is lighting up with data-backed insights.

PRO reveals actionable edges and predictions for every game, meaning there’s a genuine opportunity to find value in the betting markets across the night.

Both sharps and experts are channeling their focus on a couple spreads. Furthermore, a unique angle has caught our attention, thanks to a betting model from our researcher.

Additionally, we’ve detected an over/under sitting significantly lower than our projections suggest.

With this wealth of information at our disposal, let’s dive into our college football Friday picks.

• Jacksonville State vs. Kennesaw State Pick — Spread (7 p.m. ET)
• Houston vs. TCU Pick — Total (7:30 p.m. ET)
• Michigan State vs. Oregon Pick — Spread (9 p.m. ET)
• Syracuse vs. UNLV Pick — Total (9 p.m. ET)

College Football Friday Picks: Week 6 Predictions for Every Game

Jacksonville State vs. Kennesaw State  Prediction Friday

First up, we have the Jacksonville State vs. Kennesaw State matchup.

Scheduled for 7 p.m. ET, this game is sparking considerable interest in sharp betting circles. Action PRO insights indicate confidence in Jacksonville State to cover the spread as a double-digit road favorite.

Kennesaw State’s track record this season has been anything but stellar, and this perception has prompted the line to move from -13.5 to -16.5 in favor of Jacksonville State. Such movement can often reflect sharp money, and with Kennesaw’s ongoing struggles, all indicators lean towards Jacksonville State covering the spread against a team our Collin Wilson rates as the third-worst in the country.

PRO College Football Friday Pick: Jacksonville State to Cover

Houston vs. TCU Prediction Friday

Another game drawing attention is Houston vs. TCU.

A fascinating insight from our researcher, Evan Abrams, highlights that Power Five conference games played on days other than Saturday tend to go under 56% of the time. Combine this with our projections, which peg the total of 50.5 closer to 48.1, and we have a compelling argument for the under.

PRO College Football Friday Pick: Houston vs. TCU Under

Michigan State vs. Oregon Prediction Friday

Moving on, Michigan State faces Oregon, and our experts are firmly backing Oregon, led by quarterback Dillon Gabriel, to cover a -23.5 spread at home.

With Oregon’s offense finding its footing and Michigan State playing in one of the loudest environments in college football, this is a bet aligned with both public and expert sentiment this college football Friday.

PRO College Football Friday Pick: Oregon to Cover

Syracuse vs. UNLV Prediction Friday

Lastly, there’s the enticing clash between Syracuse and UNLV.

Here, both our experts and PRO Projections signal a favorable outcome for the over 56.5.

According to our proprietary metrics, the Syracuse vs. UNLV over/under should be more like 60. As one of our standout over/under picks, it represents an attractive opportunity for bettors looking to capitalize on the college football Friday slate.

PRO College Football Friday Pick: Syracuse vs. UNLV Over

Our PRO signals flag far more great picks than our staff could author each day — that’s where Action AI comes in. Using generative AI, signals that hit a high grade threshold are written up into articles that are then vetted and edited by a human to help us get you all the sharp action. Read more about how it works here.