When is the Chicago Cubs vs. San Diego Padres game?

Wednesday, April 16, 2025. The Chicago Cubs and San Diego Padres wrap up their series at Petco Park in San Diego, California this afternoon.

What time does the Chicago Cubs vs. San Diego Padres game start?

The first pitch is scheduled for 1:10 PM PST.

How can I watch the Chicago Cubs vs. San Diego Padres game today?

You can watch the game on SDPA and MARQ. It’s also available via livestream on Hulu + Live TV, Fubo, and Padres.tv (regional restrictions may apply).

Where is the Cubs vs. Padres game being played?

The game is being played at Petco Park in San Diego, California.

What are the odds for the Chicago Cubs vs. San Diego Padres game today?

The run line is currently +1.5 for the Chicago Cubs and -1.5 for the San Diego Padres, with run line odds set at -207 for the Cubs and +170 for the Padres.

Why are the Chicago Cubs favored to win over the Padres?

The Cubs are 7-9 this year when favored by the stat line. They were favored on Tuesday night and won in extra innings, handing the Padres their first home loss of the season. While the Padres have been nearly unstoppable at Petco Park, the oddsmakers remain confident in Chicago again today.

Who are the starting pitchers for the Cubs vs. Padres game?

Padres right-handed pitcher Nick Pivetta (1.59 ERA) squares off against Cubs left-handed pitcher Matthew Boyd (1.59 ERA). Both are having outstanding seasons so far.

How have the San Diego Padres started their 2025 MLB season?

The Padres opened their season with a 7-0 run, sweeping the Braves and Guardians at home to set a new franchise record. Despite dropping last night’s game in extra innings, they remain an impressive 11-1 at Petco Park and are off to one of the best starts in club history.

How did the Padres finally lose at home?

The Cubs snapped the Padres’ undefeated home streak on Tuesday, beating them 2-1 in the 10th inning. It was San Diego’s first loss at Petco Park in 2025, giving the team an 11-1 home record.

Who are the key players to watch on the Chicago Cubs?

Carson Kelly has been spectacular, batting .417 with 4 home runs, 13 RBIs, and a 1.636 OPS in just 9 games. Kyle Tucker is slashing .313/.427/.600 with 5 homers, 18 RBIs, and 4 stolen bases. Michael Busch adds more pop, hitting .302 with 4 home runs and a .983 OPS.

Who are the key players to watch on the San Diego Padres?

Fernando Tatis Jr. is hitting .354 with 6 home runs, 12 RBIs, and a 1.073 OPS, plus 6 stolen bases. Rookie Jackson Merrill owns a .378 average with 3 homers and 10 RBIs in 10 games. Manny Machado is batting .313 with 7 doubles, 6 steals, and an .894 OPS.

What are the key stats for the Chicago Cubs so far?

Chicago has scored 122 runs with a .257 batting average, .345 on-base percentage, and 26 home runs. Their team ERA is 4.12, with a 1.36 WHIP and 154 strikeouts.

What are the key stats for the San Diego Padres so far?

San Diego has put up 84 runs with a .277 batting average and .346 on-base percentage. They’ve hit 19 home runs and stolen 24 bases. Their pitching has been impressive, with a 2.59 ERA, 1.09 WHIP, and 156 strikeouts.

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Cubs' Dansby Swanson scores as Padres Catcher Martin Maldonado prepares to catch the thrown ball at Petco Park

Apr 15, 2025; San Diego, California, USA; Chicago Cubs shortstop Dansby Swanson (7) slides as he scores ahead of the throw to San Diego Padres catcher Martin Maldonado (15) during the sixth inning at Petco Park. Mandatory Credit: Denis Poroy-Imagn Images

How to Watch the Chicago Cubs vs. the San Diego Padres: First pitch, TV & streaming details for today's afternoon game

By Matt Buxbaum | Last updated Apr 16, 2025 12:55 PM ET

Affiliate Disclosure Statement: If you make a purchase using the links included, we may earn a share of the revenue from our affiliate partners.

After a crushing blow to the Padres' at-home record last night, the team has finally been defeated at Petco Park, giving the San Diego Padres an 11-1 record on their home turf. The Cubs beat the Padres in the 10th inning with a final score of 2-1. This just delivered the fourth loss of the entire 2025 Padres season so far.

The San Diego Padres have had a historic start to their 2025 MLB season, going 7-0 by sweeping the Atlanta Braves and Cleveland Guardians at Petco Park. This set a Padres record for the best season-opening streak in the team's franchise history.

Today, the San Diego Padres will have one more game against the Chicago Cubs. The Padres will look to take the series and move forward with a hopeful 15-4 record as they go on the road to face the Astros.

The Padres will start right-handed pitcher Nick Pivetta, and the Cubs will start left-handed pitcher Matthew Boyd. Both pitchers are having phenomenal years, earning each a current 1.59 ERA.

How to watch the Chicago Cubs vs. San Diego Padres game today

Matchup: Chicago Cubs vs. San Diego Padres
Date: Wednesday, April 16, 2025
Time: 1:10 PM PST
TV Channels: SDPA and MARQ
Livestreaming Platforms: Hulu + Live TV, Fubo, and Padres.tv (regional restrictions may apply)
Location: San Diego, California
Stadium: Petco Park

Predictions, odds, and spread for Chicago Cubs vs. San Diego Padres

Key Line	Chicago Cubs	San Diego Padres
Run Line	+1.5	-1.5
Run Line Odds	-207	+170

With the Padres' performance for 2025, what's with the Cubs being favored today?

The short answer: Simply put, the Cubs are 7-and-9 this year when favored by the stat line. They were favored last night for Tuesday's game and subsequently won.

Key players you need to watch on the Chicago Cubs

Carson Kelly – The Cubs’ catcher has been a revelation, hitting .417 with 4 home runs and 13 RBI in just 9 games. His 1.636 OPS and 1.2 WAR lead the team, making him one of the most impactful players in limited action.
Kyle Tucker – Leading the Cubs' regulars, Tucker has delivered a strong .313/.427/.600 slash line with 5 home runs, 18 RBI, and 4 stolen bases, resulting in a 1.027 OPS and 1.1 WAR through 20 games.
Michael Busch – Providing power at first base, Busch is batting .302 with 4 home runs and a .983 OPS. His steady presence in the lineup and 0.7 WAR make him a key offensive contributor.

Key players you need to watch on the San Diego Padres

Fernando Tatis Jr. – Putting up phenomenal numbers this year, with a blistering .354 average, 6 home runs, 12 RBI, and a sky-high 1.073 OPS, Tatis is putting up MVP-worthy numbers. Plus, he’s stolen bases...6 times already.
Jackson Merrill – The rookie sensation is swinging like a seasoned vet, slashing .378/.415/.676 with 3 homers and 10 RBI in just 10 games.
Manny Machado – The captain is steering the ship. Manny’s batting .313 with 7 doubles, 6 steals, and a crisp .894 OPS. He’s doing it all — getting on base, driving runs, and anchoring the infield.

Key stats for Chicago Cubs

TEAM	R	AVG	OBP	SLG	OPS	HR	SB	ERA	WHIP	K
Chicago Cubs	122	.257	.345	.436	.780	26	29	4.12	1.36	154

Key stats for San Diego Padres

TEAM	R	AVG	OBP	SLG	OPS	HR	SB	ERA	WHIP	K
San Diego Padres	84	.277	.346	.423	.769	19	24	2.59	1.09	156

Who's winning the Chicago Cubs vs. San Diego Padres series?

Well, the Cubs played like a World Series team last night and broke the Padres winning streak at home. Unfortunately, the odds have the Cubs winning today's afternoon matchup — so far, when the Cubs are favored, they win. It looks as though the Padres may be delivered their fifth loss today.